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Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace. George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and [...]

As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

As preparations continue for Meredith and Derek’s wedding, several residents must face the arrival of their parents at the hospital: Izzie’s mother Robbie causes a stir when she pays a surprise visit, and Thatcher returns to make amends with Meredith and Lexie. The Chief clashes with Meredith over a controversial medical case.

Amidst a series of intense treatments, Izzie throws herself into Derek and Meredith’s wedding plans, but the stress of her illness takes its toll on Alex – who freezes during surgery just as George begins to excel. Meanwhile: Callie’s father arrives at Seattle Grace, but is less than pleased to meet his daughter’s girlfriend; Owen [...]

All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.